2009, discovery of a brand new phenotype for microorganisms in slender nanofluidic slits; and to start with detection of local protein structures along DNA making use of reliable-condition nanopores

Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.

[Laughs] ‘It had been undoubtedly an incredible possibility! At enough time, I used to be nicely conscious that it could go wrong Which I could come to be a lot less profitable, but I just dismissed that. Curiosity has usually been my strongest driving force. And fortunately all of it labored out.’

Non-equilibrium folding of unique DNA molecules recaptured up to a thousand occasions inside a strong state nanopore

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Microbiology has only existed for your century, considering the fact that we started to examine micro-organisms additional very seriously. I assumed nanobiology was an appropriate term, since all molecular biological pertinent interactions happen on the nanoscale: a protein is a number of nanometres in sizing, DNA is two nm thick.’

We use nanofabricated microfluidic constructions to sample spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental function of spatial confinement in the molecular and cellular level. Our jobs involve the subsequent:

Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation

Imagine if, rather than utilizing common top rated-down silicon electronics, transistors may be constructed from the bottom up employing solitary organic and natural molecules since the switching elements? This idea, which grew to become the basis of now’s discipline of molecular electronics, to start with emerged inside the seventies.

It was through this era that Dekker performed study on magnetic spin techniques and on sound in superconductors and semiconductors.

In 1993 he was appointed as Affiliate Professor at Delft University of Technologies. While in the mid-nineteen nineties Dekker and his group reached success with the discovery on the electronic Houses of carbon nanotubes, the initial single-molecule transistor as well as other nanoscience.

1999, 1st measurement of the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for any new Luttinger description of interacting electrons in nanotubes

2005, discovery on the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-array conformational alterations in Mre11/DNA restore complexes; and to start with pressure measurements on the DNA https://www.ceesdekker.net molecule inside of a nanopore

‘I'm pushed by wonder and queries. On a fabric amount I discover solutions in physics, but I working experience my deepest happiness with God. That faith also drives my science And the way I take care of persons.